Peptide Active Data Details
Basic Peptide Information
DICL ID
DICL_Pep_00108
Ion Channel
Voltage-gated potassium channel subfamily D member 2
Peptide Function
Inhibitor
Gene Name
KCND2
Activity Data (nM)
IC50
Not available
Ki
Not available
EC50
850 nM
Kd
Not available
Biologically Active
Not specified
Sequence Information
Peptide Sequence
VGCEECPMHCKGKNAKPTCDDGVCNCNV
Peptide UniProt Accession
Not available
UniParc
UPI00001110E8
Peptide Synonyms/Alias
BmP02
Peptide Species
Not specified
Peptide Name
Not available
CAS Number
Not available
Experimental Conditions
pH
pH 7.4
Holding Potential (mV)
−100 mV
Temperature
21–25 °C
Test Method
Patch-clamping
Test Species
HEK293T cell (Homo sapiens embryonic kidney 293T cell)
Binding Information
Binding Site
Extracellular domain
Binding Site Residue
Three negative amino acids (A359, K347, K353) within the pore of Voltage-gated potassium channel subfamily D member 2 channels and positive residues E4/E5 and D20/D21 on the toxin facilitate the interaction between the channel and the toxin
Ion Channel Information
Gene Abbreviation (ABB)
VGKCs
Ion Channel UniProt Accession
Source Organism
Homo sapiens (Human)
References & Disease Information
Disease
Not specified
PubChem CID
Not available
URL
Not available
PMID
Patent
Not available